https://weaverlab.science/home daily 1.0 2025-06-11 https://weaverlab.science/research daily 0.75 2023-01-01 https://images.squarespace-cdn.com/content/v1/5edf95848a3692763892e65d/1593363694731-937BSB98YGJNENAK3BVT/NRs.png Weaver Lab Research - Nuclear receptors as a model. Nuclear receptors are widely expressed transcription factors that are essential for development, metabolic processes, and reproduction. Many circulating factors including steroid hormones, lipids, and other lipophilic molecules function as ligands for nuclear receptors, making them ideal models to understand how signaling from peripheral tissues influence oogenesis. https://images.squarespace-cdn.com/content/v1/5edf95848a3692763892e65d/1594318105370-GYFOVBY6NOLWHERGC15Q/Ovary.png Weaver Lab Research - The Drosophila ovary as a model. Similarly to humans, the Drosophila ovary is regulated by hormone & steroid signaling, making it an excellent model to understand nuclear receptor control of oogenesis and stem cell lineages. The ovary is composed of a germarium & progressively older follicles. The germarium contains the niche - terminal filament & cap cells, germline and somatic stem cell populations, and their progeny. https://images.squarespace-cdn.com/content/v1/5edf95848a3692763892e65d/1593363747530-C60G2ZXEKNPFI7KLZMHJ/organs.png Weaver Lab Research - Nuclear receptors as a model to understand stem cell lineages. Most studies have focused on how an individual nuclear receptor acts within a specific cell type or tissue itself to control transcripts that directly influence that tissue of interest. However, nuclear receptors can act on a variety of tissues. Therefore, it is important to think about how they may have direct and perhaps indirect functions in other tissues. https://weaverlab.science/contact daily 0.75 2020-07-09 https://images.squarespace-cdn.com/content/v1/5edf95848a3692763892e65d/1592875605129-FU68O6LYHRO2E5IQOR5Y/3EC4EA15-F218-4593-A1E1-CF0797DCEA24.jpg Contact https://weaverlab.science/publications daily 0.75 2025-09-14 https://weaverlab.science/weaverlabmembers daily 0.75 2026-01-07 https://images.squarespace-cdn.com/content/v1/5edf95848a3692763892e65d/1ca2b205-a0c4-416f-b236-cdcfa49e7aa8/Madelyn+H.jpg People - Make it stand out Madelyn Haley Undergraduate Researcher https://images.squarespace-cdn.com/content/v1/5edf95848a3692763892e65d/7e1ab7dd-b701-40e9-a210-565499965e67/Alex+Warren.jpg People - Make it stand out Alexandria Warren CMCB PhD Student https://images.squarespace-cdn.com/content/v1/5edf95848a3692763892e65d/3a8fd8c5-9aa6-4249-914f-fa5a630345a6/IMG_1503.jpg People - Zoey Weaver Zoey Weaver Lab Morale Officer https://images.squarespace-cdn.com/content/v1/5edf95848a3692763892e65d/97ab9e5d-bbeb-4360-8437-c8e23f1f298e/Mekenzi.png People - Allison Simmons Mekenzi Hazen Research Associate https://images.squarespace-cdn.com/content/v1/5edf95848a3692763892e65d/ffc02baa-75dd-4e04-be0e-92b77f5a3ca0/Carolina.jpg People - Make it stand out Carolina Rodrigues Undergraduate Lab Assistant https://images.squarespace-cdn.com/content/v1/5edf95848a3692763892e65d/1593290826796-MAN0O0LQGSN9ZQEZTUHX/LesleyWeaver-0725-E.jpg People - Lesley Weaver, Ph.D. Principal Investigator Asst. Professor of Biology https://images.squarespace-cdn.com/content/v1/5edf95848a3692763892e65d/9bd96d7d-57ed-47ca-9029-9d2803e5caa3/Ellie+Goldstone.png People - Anna De Varona Ellie Goldstone Research Associate https://images.squarespace-cdn.com/content/v1/5edf95848a3692763892e65d/a12bbfc1-251b-4297-b8db-f0d555d18b2d/Jitika+Bhatta.jpg People - Make it stand out Jitika Bhatta GCDB PhD Student